Neuronal actin dynamics, spine density and neuronal dendritic complexity are regulated by CAP2

Neuronal actin dynamics, spine density and neuronal dendritic complexity are regulated by CAP2

Actin remodeling is crucial for dendritic spine development, morphology and density. CAP2 is a regulator of actin dynamics through sequestering G-actin and severing F-actin. In a mouse model, ablation of CAP2 leads to cardiovascular defects and delayed wound healing. This report investigates the rol...

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Bibliographic Details
Main Authors: Atul Kumar, Lars Paeger, Kosmas Kosmas, Peter Kloppenburg, Angelika Noegel, Vivek Peche
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Actins
Dendritic Spines
AMPA receptors
actin binding proteins
Cyclase associated protein
CAP2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00180/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00180/full

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