Predicting the structure of large protein complexes using AlphaFold and Monte Carlo tree search

Predicting the structure of large protein complexes using AlphaFold and Monte Carlo tree search

The accuracy of AlphaFold decreases with the number of protein chains and the available GPU memory limits the size of protein complexes that can be predicted. Here, the authors show that complexes with 10–30 chains can be assembled from predicted subcomponents using Monte Carlo tree search.

Bibliographic Details
Main Authors: Patrick Bryant, Gabriele Pozzati, Wensi Zhu, Aditi Shenoy, Petras Kundrotas, Arne Elofsson
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33729-4

Internet

https://doi.org/10.1038/s41467-022-33729-4

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