CRISPR Deletion of a SVA Retrotransposon Demonstrates Function as a <i>cis</i>-Regulatory Element at the <i>TRPV1/TRPV3</i> Intergenic Region

CRISPR Deletion of a SVA Retrotransposon Demonstrates Function as a <i>cis</i>-Regulatory Element at the <i>TRPV1/TRPV3</i> Intergenic Region

SINE-VNTR-<i>Alu</i> (SVA) retrotransposons are a subclass of transposable elements (TEs) that exist only in primate genomes. TE insertions can be co-opted as <i>cis</i>-regulatory elements (CREs); however, the regulatory potential of SVAs has predominantly been demonstrated...

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Bibliographic Details
Main Authors: Emma Price, Olympia Gianfrancesco, Patrick T. Harrison, Bernhard Frank, Vivien J. Bubb, John P. Quinn
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
retrotransposon
SVA
<i>cis</i>-regulatory element
<i>TRPV1</i>
<i>TRPV3</i>
CRISPR
Online Access:https://www.mdpi.com/1422-0067/22/4/1911

Internet

https://www.mdpi.com/1422-0067/22/4/1911

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