Synthesis of Celecoxib-Eutectic Mixture Particles via Supercritical CO<sub>2</sub> Process and Celecoxib Immediate Release Tablet Formulation by Quality by Design Approach

Synthesis of Celecoxib-Eutectic Mixture Particles via Supercritical CO<sub>2</sub> Process and Celecoxib Immediate Release Tablet Formulation by Quality by Design Approach

Significant improvements in the wettability and dissolution rate of celecoxib (CEL), a poorly soluble selective cyclooxygenase-2 (COX-2) inhibitor, have been shown by Huyn et al., 2019 by combining the binary pharmaceutical compositions including CEL and one of the two co-formers, adipic acid (ADI)...

Full description

Bibliographic Details
Main Authors: Seung-Hyeon Hong, Linh Dinh, Sharif Md Abuzar, Eun Seok Lee, Sung-Joo Hwang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
celecoxib
supercritical fluid
eutectic mixture
adipic acid
saccharin
spray drying
Online Access:https://www.mdpi.com/1999-4923/14/8/1549

Internet

https://www.mdpi.com/1999-4923/14/8/1549

Similar Items