Vitamin B<sub>12</sub> deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse

Vitamin B<sub>12</sub> deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse

<p>Abstract</p> <p>Background</p> <p>DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B<sub>12</sub> and folate pathways are involved in the production of S-Adenosylmethionine, th...

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Bibliographic Details
Main Authors:	Fernàndez-Roig Sílvia, Lai Shao-Chiang, Murphy Michelle M, Fernandez-Ballart Joan, Quadros Edward V
Format:	Article
Language:	English
Published:	BMC 2012-05-01
Series:	Nutrition & Metabolism
Subjects:	Vitamin B<sub>12</sub> deficiency Brain Global DNA methylation Transcobalamin receptor knock out mice
Online Access:	http://www.nutritionandmetabolism.com/content/9/1/41

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