Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models.

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models.

Current treatments available for African sleeping sickness or human African trypanosomiasis (HAT) are limited, with poor efficacy and unacceptable safety profiles. Here, we report a new approach to address treatment of this disease based on the use of compounds that bind to parasite surface glycans...

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Bibliographic Details
Main Authors: Víctor M Castillo-Acosta, Luis M Ruiz-Pérez, Juan Etxebarria, Niels C Reichardt, Miguel Navarro, Yasuhiro Igarashi, Sandra Liekens, Jan Balzarini, Dolores González-Pacanowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5035034?pdf=render

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http://europepmc.org/articles/PMC5035034?pdf=render

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