The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo

The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo

Abstract Background While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the mechanisms regulating metastasis formation is essential to develop ther...

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Bibliographic Details
Main Authors: Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann, Taronish D. Dubash, Klara M. Giessler, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm, Claudia R. Ball
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Metastasis
Xenotransplantation
HEYL
Online Access:https://doi.org/10.1186/s12885-019-6396-4

Internet

https://doi.org/10.1186/s12885-019-6396-4

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