Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties – Synthesis and biological activity

Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties – Synthesis and biological activity

2-Azabicycloalkanes: 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[3.2.1]octane were used as a chiral platform for the construction of a set of 1,2,3-triazole, thiourea, and ebselen derivatives. Cytotoxicity and antiviral activity studies revealed the most promising potency for selected thioureas.

Bibliographic Details
Main Authors: Franz Steppeler, Dominika Iwan, Radosław Gaida, Marta Denel-Bobrowska, Agnieszka B. Olejniczak, Elżbieta Wojaczyńska
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Antiviral activity
2-azabicycloalkane
Cytotoxicity
Ebselen
Thiourea
1,2,3-triazole
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223006984

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223006984

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