Proviruses with Long-Term Stable Expression Accumulate in Transcriptionally Active Chromatin Close to the Gene Regulatory Elements: Comparison of ASLV-, HIV- and MLV-Derived Vectors

Proviruses with Long-Term Stable Expression Accumulate in Transcriptionally Active Chromatin Close to the Gene Regulatory Elements: Comparison of ASLV-, HIV- and MLV-Derived Vectors

Individual groups of retroviruses and retroviral vectors differ in their integration site preference and interaction with the host genome. Hence, immediately after infection genome-wide distribution of integrated proviruses is non-random. During long-term in vitro or persistent in vivo infection, th...

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Bibliographic Details
Main Authors: Dalibor Miklík, Filip Šenigl, Jiří Hejnar
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Viruses
Subjects:
retrovirus integration
provirus silencing
gene regulatory elements
genome-wide provirus distribution
Online Access:http://www.mdpi.com/1999-4915/10/3/116

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http://www.mdpi.com/1999-4915/10/3/116

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