Hats off to 20S proteasome substrate discovery

Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S pr...

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Bibliographic Details
Main Authors: Taylor R Church, Anna Brennan, Seth S Margolis
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:Molecular Systems Biology
Online Access:https://doi.org/10.1038/s44320-024-00028-7