Hats off to 20S proteasome substrate discovery
Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S pr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2024-03-01
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| Series: | Molecular Systems Biology |
| Online Access: | https://doi.org/10.1038/s44320-024-00028-7 |
| _version_ | 1797219483011514368 |
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| author | Taylor R Church Anna Brennan Seth S Margolis |
| author_facet | Taylor R Church Anna Brennan Seth S Margolis |
| author_sort | Taylor R Church |
| collection | DOAJ |
| description | Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome. |
| first_indexed | 2024-04-24T12:34:21Z |
| format | Article |
| id | doaj.art-ba1d3bea6faf4669a1c420cf59d616a7 |
| institution | Directory Open Access Journal |
| issn | 1744-4292 |
| language | English |
| last_indexed | 2024-04-24T12:34:21Z |
| publishDate | 2024-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj.art-ba1d3bea6faf4669a1c420cf59d616a72024-04-07T11:35:04ZengSpringer NatureMolecular Systems Biology1744-42922024-03-0120429329510.1038/s44320-024-00028-7Hats off to 20S proteasome substrate discoveryTaylor R Church0Anna Brennan1Seth S Margolis2Department of Biological Chemistry, The Johns Hopkins University School of MedicineDepartment of Biological Chemistry, The Johns Hopkins University School of MedicineDepartment of Biological Chemistry, The Johns Hopkins University School of MedicineUncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome.https://doi.org/10.1038/s44320-024-00028-7 |
| spellingShingle | Taylor R Church Anna Brennan Seth S Margolis Hats off to 20S proteasome substrate discovery Molecular Systems Biology |
| title | Hats off to 20S proteasome substrate discovery |
| title_full | Hats off to 20S proteasome substrate discovery |
| title_fullStr | Hats off to 20S proteasome substrate discovery |
| title_full_unstemmed | Hats off to 20S proteasome substrate discovery |
| title_short | Hats off to 20S proteasome substrate discovery |
| title_sort | hats off to 20s proteasome substrate discovery |
| url | https://doi.org/10.1038/s44320-024-00028-7 |
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