Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation

Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation

Background: Serum & Glucocorticoid Regulated Kinase 1 (SGK1) plays a fundamental role in ion and solute transport processes in epithelia. In the endometrium, down-regulation of SGK1 during the window of receptivity facilitates embryo implantation whereas expression of a constitutively active...

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Bibliographic Details
Main Authors: Madhuri S. Salker, Jennifer H. Steel, Zohreh Hosseinzadeh, Jaya Nautiyal, Zoe Webster, Yogesh Singh, Sara Brucker, Florian Lang, Jan J. Brosens
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Serum/Glucocorticoid Regulated Kinase 1
Epithelial Na+ channel (ENaC)
Nedd4-2
Implantation failure
Online Access:http://www.karger.com/Article/FullText/447903

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http://www.karger.com/Article/FullText/447903

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