Assessment of UL56 Mutations before Letermovir Therapy in Refractory Cytomegalovirus Transplant Recipients

Assessment of UL56 Mutations before Letermovir Therapy in Refractory Cytomegalovirus Transplant Recipients

ABSTRACT De novo mutations in the UL56 terminase subunit and its associated phenotypes were studied in the context of cytomegalovirus (CMV) transplant recipients clinically resistant to DNA-polymerase inhibitors, naive to letermovir. R246C was the only UL56 variant detected by standard and deep sequ...

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Bibliographic Details
Main Authors: Marta Santos Bravo, Valentin Tilloy, Nicolas Plault, Sonsoles Sánchez Palomino, María Mar Mosquera, Mireia Navarro Gabriel, Francesc Fernández Avilés, María Suárez Lledó, Montserrat Rovira, Asunción Moreno, Laura Linares, Marta Bodro, Sébastien Hantz, Sophie Alain, María Ángeles Marcos
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
cytomegalovirus
letermovir
baseline mutations
transplant recipients
phenotype
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00191-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00191-22

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