Characterization of the tumor microenvironment and identification of spatially predictive biomarkers associated with beneficial neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Characterization of the tumor microenvironment and identification of spatially predictive biomarkers associated with beneficial neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for patients with locally advanced rectal cancer (LARC). However, 20–40% of patients with LARC show little to no response to nCRT. Thus, comprehensively understanding the tumor microenvironment (TME), which might influence therap...

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Bibliographic Details
Main Authors: Shifen Zhang, Na Li, Feifei Wang, Hailing Liu, Yuhan Zhang, Jinyuan Xiao, Weihao Qiu, Ceng Zhang, Xinjuan Fan, Mingxin Qiu, Mingzhou Li, Hongzhen Tang, Shiheng Fan, Jiaqian Wang, Haitao Luo, Xiangzhao Li, Jie Lin, Yan Huang, Li Liang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Pharmacological Research
Subjects:
Locally advanced rectal cancer
Neoadjuvant chemoradiotherapy
Tumor microenvironment
Biomarkers
Digital spatial profiling
Multiplex immunofluorescence
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823003304

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http://www.sciencedirect.com/science/article/pii/S1043661823003304

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