Yap signalling regulates ductular reactions in mice with CRISPR/Cas9-induced glycogen storage disease type Ia

Yap signalling regulates ductular reactions in mice with CRISPR/Cas9-induced glycogen storage disease type Ia

ABSTRACTGlycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in the glucose-6-phosphatase (G6Pase, G6pc) enzyme, which catalyses the final step of gluconeogenesis and glycogenolysis. Accumulation of G6pc can lead to an increase in glycogen and development of fatty liver. Ductular reac...

Full description

Bibliographic Details
Main Authors: Yixia Xie, Baowei Hu, Yue Gao, Yaxin Tang, Guohe Chen, Jiayuan Shen, Zhikai Jiang, He Jiang, Jiwei Han, Junyan Yan, Lifang Jin
Format: Article
Language:English
Published: Taylor & Francis Group 2022-11-01
Series:Animal Cells and Systems
Subjects:
GSD-Ia
ductular reactions
yap
CRISPR-Cas9
G6pc
Online Access:https://www.tandfonline.com/doi/10.1080/19768354.2022.2139755

Internet

https://www.tandfonline.com/doi/10.1080/19768354.2022.2139755

Similar Items