mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

While mRNA vaccines are proving highly efficacious against SARS-CoV-2, it is important to determine how booster doses and prior infection influence the immune defense they elicit, and whether they protect against variants. Focusing on the T cell response, we conducted a longitudinal study of infecti...

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Bibliographic Details
Main Authors: Jason Neidleman, Xiaoyu Luo, Matthew McGregor, Guorui Xie, Victoria Murray, Warner C Greene, Sulggi A Lee, Nadia R Roan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
COVID-19
SARS-CoV-2
mRNA vaccine
antigen-specific T cells
CyTOF
lymphocyte subsets
Online Access:https://elifesciences.org/articles/72619

Internet

https://elifesciences.org/articles/72619

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