Elucidating the role of 4-hydroxy-2(3H)-benzoxazolone in chronic alcoholic liver disease via transcriptomics and metabolomics

Elucidating the role of 4-hydroxy-2(3H)-benzoxazolone in chronic alcoholic liver disease via transcriptomics and metabolomics

BackgroundChronic alcoholic liver disease (CALD) is a global health problem which includes multiple pathological processes such as immune inflammation and oxidative stress. 4-hydroxy-2(3H)-benzoxazolone (HBOA), an alkaloid isolated from Acanthus ilicifolius L, has been shown to exert hepatoprotectiv...

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Main Authors: Jun-Fei Lu, Shang-Ping Xing, Xia Wei, Chun-Xia Yang, Gen-Shi Zhao, Xiao-Lin Ma, Xue-Mei Sun, Hong-Wei Guo, Zhi-Heng Su, Bin Fang, Jun Lin, Yan-Ying Liu, Dan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
chronic alcoholic liver disease
4-hydroxy-2(3H)-benzoxazolone
oxidative stress
immune inflammation
transcriptomics
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1447560/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1447560/full

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