The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

8-oxodeoxyguanosine (8-oxodG), a major oxidised base modification, has been investigated to study its impact on DNA replication in hyperthermophilic Archaea. Here we show that 8-oxodG is formed in the genome of growing cells, with elevated levels following exposure to oxidative stress. Functional ch...

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Bibliographic Details
Main Authors: Tom Killelea, Adeline Palud, Farida Akcha, Mélanie Lemor, Stephane L'haridon, Anne Godfroy, Ghislaine Henneke
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
Pyrococcus abyssi
DNA polymerases
8-oxodeoxyguanosine
DNA replication
oxidative stress
accessory factors
Online Access:https://elifesciences.org/articles/45320

Internet

https://elifesciences.org/articles/45320

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