Angioimmunoblastic T-cell lymphoma with predominant CD8+ tumor-infiltrating T-cells is a distinct immune pattern with an immunosuppressive microenvironment

Angioimmunoblastic T-cell lymphoma with predominant CD8+ tumor-infiltrating T-cells is a distinct immune pattern with an immunosuppressive microenvironment

BackgroundAngioimmunoblastic T-cell lymphoma (AITL) has a rich tumor microenvironment (TME) that typically harbors plenty of CD4+tumor infiltrating lymphocytes, (TIL)-T-cells (so called common AITL). Nonetheless, AITL with large numbers of CD8+TIL-Ts that outnumber CD4+cells have been observed (CD8-...

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Bibliographic Details
Main Authors: Zihang Chen, Qiqi Zhu, Xueqin Deng, Wenqing Yao, Wenyan Zhang, Weiping Liu, Yuan Tang, Sha Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
angioimmunoblastic T-cell lymphoma
tumor microenvironment
T cell receptor-β repertoire
immunoglobulin heavy chain repertoire
TME function
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.987227/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.987227/full

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