Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients

Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients

Abstract The possible role of somatic copy number variations (CNVs) in Alzheimer’s disease (AD) aetiology has been controversial. Although cytogenetic studies suggested increased CNV loads in AD brains, a recent single-cell whole-genome sequencing (scWGS) experiment, studying frontal cortex brain sa...

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Bibliographic Details
Main Authors: Zeliha Gözde Turan, Vincent Richter, Jana Bochmann, Poorya Parvizi, Etka Yapar, Ulas Işıldak, Sarah-Kristin Waterholter, Sabrina Leclere-Turbant, Çağdaş Devrim Son, Charles Duyckaerts, İdil Yet, Thomas Arendt, Mehmet Somel, Uwe Ueberham
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Acta Neuropathologica Communications
Subjects:
Single-cell whole-genome sequencing
Copy number variation
Alzheimer’s disease
Brain
Laser capture microdissection
Fluorescence-activated cell sorting
Online Access:https://doi.org/10.1186/s40478-022-01452-2

Internet

https://doi.org/10.1186/s40478-022-01452-2

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