Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway

Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway

Osteosarcoma is a common malignant tumor occurring in children and young adults. Chondroitin sulfate (CS) participates in cell adhesion, cell division, and the formation of neural networks in the body, the biosynthesis of which requires the participation of glycosyltransferases. CHPF, a glycosyltran...

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Bibliographic Details
Main Authors: Yi Shen, Jun Li, Dan Peng, Lele Liao, Xia Chen, Weiye Zhong, Zicheng Liu, Chao Yu, Yuanliang Sun
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-09-01
Series:Genes and Diseases
Subjects:
Akt signaling pathway
CHPF
Osteosarcoma
SKP2
Ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304222002033

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http://www.sciencedirect.com/science/article/pii/S2352304222002033

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