Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice.

We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2 (-/)NO3 (-) data from "middle-aged" (6-8 months old) C57BL/6 mice were used to re-parame...

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Bibliographic Details
Main Authors: Rami A Namas, John Bartels, Rosemary Hoffman, Derek Barclay, Timothy R Billiar, Ruben Zamora, Yoram Vodovotz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3699569?pdf=render