Study of Combinatorial Drug Synergy of Novel Acridone Derivatives With Temozolomide Using in-silico and in-vitro Methods in the Treatment of Drug-Resistant Glioma

Study of Combinatorial Drug Synergy of Novel Acridone Derivatives With Temozolomide Using in-silico and in-vitro Methods in the Treatment of Drug-Resistant Glioma

Drug resistance is one of the critical challenges faced in the treatment of Glioma. There are only limited drugs available in the treatment of Glioma and among them Temozolomide (TMZ) has shown some effectiveness in treating Glioma patients, however, the rate of recovery remains poor due to the inab...

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Bibliographic Details
Main Authors: Malobika Chakravarty, Piyali Ganguli, Manikanta Murahari, Ram Rup Sarkar, Godefridus Johannes Peters, Y. C. Mayur
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
acridone derivatives
drug combinations
synergy index
mathematical model
Glioma
drug resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.625899/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.625899/full

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