The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?
Abstract Systemic sclerosis is considered a disease dominated by a “loss of angiogenesis”, although in its early phases evidence indicates a disturbed angiogenic response only. In fact, microvascular changes are primarily due to endothelial cell injury, triggering downstream significant enlargement...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-017-1370-5 |
| _version_ | 1818694415240134656 |
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| author | Marco Matucci-Cerinic Mirko Manetti Cosimo Bruni Ines Chora Silvia Bellando-Randone Gemma Lepri Amato De Paulis Serena Guiducci |
| author_facet | Marco Matucci-Cerinic Mirko Manetti Cosimo Bruni Ines Chora Silvia Bellando-Randone Gemma Lepri Amato De Paulis Serena Guiducci |
| author_sort | Marco Matucci-Cerinic |
| collection | DOAJ |
| description | Abstract Systemic sclerosis is considered a disease dominated by a “loss of angiogenesis”, although in its early phases evidence indicates a disturbed angiogenic response only. In fact, microvascular changes are primarily due to endothelial cell injury, triggering downstream significant enlargement of the capillary in an inflammatory environment, followed by capillary rupture (microhemorrhages). Subsequent pro-angiogenic efforts lead to an aberrant angiogenesis and, eventually, to a total loss of vessel repair and regeneration (loss of angiogenesis). This clearly suggests that the pathogenetic process has a steady progression: from an early excessive pro-angiogenesis, to an aberrant microvascular regeneration, then ending with a late loss of angiogenesis. Herein, we suggest the loss of angiogenesis should not be considered as an overall “myth” characterizing systemic sclerosis but as a very late event of the vascular pathogenesis. Future research should be oriented essentially on the earlier phases dominated by excessive pro-angiogenesis and microvascular aberration. |
| first_indexed | 2024-12-17T13:29:13Z |
| format | Article |
| id | doaj.art-ba370777d8144916a6d586748a047b3f |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-17T13:29:13Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-ba370777d8144916a6d586748a047b3f2022-12-21T21:46:39ZengBMCArthritis Research & Therapy1478-63622017-07-011911410.1186/s13075-017-1370-5The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?Marco Matucci-Cerinic0Mirko Manetti1Cosimo Bruni2Ines Chora3Silvia Bellando-Randone4Gemma Lepri5Amato De Paulis6Serena Guiducci7Department of Experimental and Clinical Medicine, Division of Rheumatology and Scleroderma Unit, Azienda Ospedaliera Universitaria Careggi, University of FlorenceDepartment of Experimental and Clinical Medicine, Division of Rheumatology and Scleroderma Unit, Azienda Ospedaliera Universitaria Careggi, University of FlorenceDepartment of Experimental and Clinical Medicine, Division of Rheumatology and Scleroderma Unit, Azienda Ospedaliera Universitaria Careggi, University of FlorenceDepartment of Internal Medicine, São João Hospital CenterDepartment of Experimental and Clinical Medicine, Division of Rheumatology and Scleroderma Unit, Azienda Ospedaliera Universitaria Careggi, University of FlorenceDepartment of Experimental and Clinical Medicine, Division of Rheumatology and Scleroderma Unit, Azienda Ospedaliera Universitaria Careggi, University of FlorenceDepartment of Translational Medical Sciences, Centre for Basic and Clinical Immunology Research (CISI), University of Naples Federico IIDepartment of Experimental and Clinical Medicine, Division of Rheumatology and Scleroderma Unit, Azienda Ospedaliera Universitaria Careggi, University of FlorenceAbstract Systemic sclerosis is considered a disease dominated by a “loss of angiogenesis”, although in its early phases evidence indicates a disturbed angiogenic response only. In fact, microvascular changes are primarily due to endothelial cell injury, triggering downstream significant enlargement of the capillary in an inflammatory environment, followed by capillary rupture (microhemorrhages). Subsequent pro-angiogenic efforts lead to an aberrant angiogenesis and, eventually, to a total loss of vessel repair and regeneration (loss of angiogenesis). This clearly suggests that the pathogenetic process has a steady progression: from an early excessive pro-angiogenesis, to an aberrant microvascular regeneration, then ending with a late loss of angiogenesis. Herein, we suggest the loss of angiogenesis should not be considered as an overall “myth” characterizing systemic sclerosis but as a very late event of the vascular pathogenesis. Future research should be oriented essentially on the earlier phases dominated by excessive pro-angiogenesis and microvascular aberration.http://link.springer.com/article/10.1186/s13075-017-1370-5SclerodermaSystemic sclerosisAngiogenesis |
| spellingShingle | Marco Matucci-Cerinic Mirko Manetti Cosimo Bruni Ines Chora Silvia Bellando-Randone Gemma Lepri Amato De Paulis Serena Guiducci The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event? Arthritis Research & Therapy Scleroderma Systemic sclerosis Angiogenesis |
| title | The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event? |
| title_full | The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event? |
| title_fullStr | The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event? |
| title_full_unstemmed | The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event? |
| title_short | The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event? |
| title_sort | myth of loss of angiogenesis in systemic sclerosis a pivotal early pathogenetic process or just a late unavoidable event |
| topic | Scleroderma Systemic sclerosis Angiogenesis |
| url | http://link.springer.com/article/10.1186/s13075-017-1370-5 |
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