Bio- and Hemo-Compatible Silk Fibroin PEGylated Nanocarriers for 5-Fluorouracil Chemotherapy in Colorectal Cancer: In Vitro Studies

Bio- and Hemo-Compatible Silk Fibroin PEGylated Nanocarriers for 5-Fluorouracil Chemotherapy in Colorectal Cancer: In Vitro Studies

5-fluorouracil (5-FU) remains the gold standard of treatment for colorectal cancer, but its poor bioavailability and high systemic toxicity highlight the urgent need for the development of novel delivery strategies to increase the efficacy of 5-FU treatment. The present study is aimed to design and...

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Bibliographic Details
Main Authors: Ariana Hudiță, Ionuț Cristian Radu, Cătălin Zaharia, Andreea Cristina Ion, Octav Ginghină, Bianca Gălățeanu, Luminița Măruțescu, Florin Grama, Aristidis Tsatsakis, Leonid Gurevich, Marieta Costache
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
5FU
polymeric nanoparticles
drugs delivery systems
colorectal cancer
cytotoxicity
inflammation
Online Access:https://www.mdpi.com/1999-4923/13/5/755

Internet

https://www.mdpi.com/1999-4923/13/5/755

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