Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina

Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina

Abstract Amyloid beta (Aβ) deposits in the retina of the Alzheimer’s disease (AD) eye may provide a useful diagnostic biomarker for AD. This study focused on the relationship of Aβ with macroglia and microglia, as these glial cells are hypothesized to play important roles in homeostasis and clearanc...

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Bibliographic Details
Main Authors: Qinyuan Alis Xu, Pierre Boerkoel, Veronica Hirsch-Reinshagen, Ian R. Mackenzie, Ging-Yuek Robin Hsiung, Geoffrey Charm, Elliott F. To, Alice Q. Liu, Katerina Schwab, Kailun Jiang, Marinko Sarunic, Mirza Faisal Beg, Wellington Pham, Jing Cui, Eleanor To, Sieun Lee, Joanne A. Matsubara
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Acta Neuropathologica Communications
Subjects:
Retina
Amyloid-β
Alzheimer’s disease
Biomarker
Macroglia
Microglia
Online Access:https://doi.org/10.1186/s40478-022-01448-y

Internet

https://doi.org/10.1186/s40478-022-01448-y

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