Naringenin alters the pharmacokinetics of ranolazine in part through the inhibition of cytochrome P450 (3A4) and P-glycoprotein

Naringenin alters the pharmacokinetics of ranolazine in part through the inhibition of cytochrome P450 (3A4) and P-glycoprotein

Abstract Background This study set out to look at how naringenin affected the pharmacokinetics of ranolazine in rats. The pharmacokinetic investigation of ranolazine in rats following oral administration of ranolazine with or without coadministration of naringenin was successfully conducted using th...

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Bibliographic Details
Main Author: Faisal Alotaibi
Format: Article
Language:English
Published: SpringerOpen 2023-03-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Ranolazine
Naringenin
Pharmacokinetics
Drug-drug interaction
Area under the curve (AUC)
CYP3A4
Online Access:https://doi.org/10.1186/s43094-023-00477-1

Internet

https://doi.org/10.1186/s43094-023-00477-1

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