Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c

Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c

UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α--triggered NF-κB activation. Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune diseases induced by aberrant activation of NF...

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Bibliographic Details
Main Authors: Fangshu Wu, Junsheng Zhu, Honglin Li, Lili Zhu
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
UbcH5c
NF-κB
Ubiquitination
Ubiquitin-conjugating enzyme
Crystal structure
Inflammatory target
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516303677

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http://www.sciencedirect.com/science/article/pii/S2211383516303677

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