Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid

Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid

Abstract Although the dysregulation of bile acid (BA) composition has been associated with fibrosis progression, its precise roles in liver fibrosis is poorly understood. This study demonstrates that solute carrier family 27 member 5 (SLC27A5), an enzyme involved in BAs metabolism, is substantially...

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Bibliographic Details
Main Authors: Kang Wu, Yi Liu, Jie Xia, Jiale Liu, Kai Wang, Huijun Liang, Fengli Xu, Dina Liu, Dan Nie, Xin Tang, Ailong Huang, Chang Chen, Ni Tang
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Advanced Science
Subjects:
bile acid
early growth response protein 3
hepatic stellate cells
liver fibrosis
solute carrier family 27 member 5
Online Access:https://doi.org/10.1002/advs.202304408

Internet

https://doi.org/10.1002/advs.202304408

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