IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells

IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells

Complexes of IL-2 and JES6-1 mAb (IL-2/JES6) provide strong sustained IL-2 signal selective for CD25+ cells and thus they potently expand Treg cells. IL-2/JES6 are effective in the treatment of autoimmune diseases and in protecting against rejection of pancreatic islet allografts. However, we found...

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Bibliographic Details
Main Authors: Jakub Tomala, Petra Weberova, Barbora Tomalova, Zuzana Jiraskova Zakostelska, Ladislav Sivak, Jirina Kovarova, Marek Kovar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
il-2/anti-il-2 mab complexes
CD25
T cells
IFN-γ
LPS
hyperreactivity
Online Access:https://elifesciences.org/articles/62432

Internet

https://elifesciences.org/articles/62432

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