Impact of IgG subclass on monoclonal antibody developability

Impact of IgG subclass on monoclonal antibody developability

ABSTRACTIgG-based monoclonal antibody therapeutics, which are mainly IgG1, IgG2, and IgG4 subclasses or related variants, have dominated the biotherapeutics field for decades. Multiple laboratories have reported that the IgG subclasses possess different molecular characteristics that can affect thei...

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Bibliographic Details
Main Authors: Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Aggregates
charge variants
developability
fragments
host cell protein
IgG subclass
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2191302

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2191302

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