Impact of IgG subclass on monoclonal antibody developability
ABSTRACTIgG-based monoclonal antibody therapeutics, which are mainly IgG1, IgG2, and IgG4 subclasses or related variants, have dominated the biotherapeutics field for decades. Multiple laboratories have reported that the IgG subclasses possess different molecular characteristics that can affect thei...
Main Authors: | Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng |
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Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2023-12-01
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Series: | mAbs |
Subjects: | |
Online Access: | https://www.tandfonline.com/doi/10.1080/19420862.2023.2191302 |
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