Neuronal Protection by Ha-RAS-GTPase Signaling through Selective Downregulation of Plasmalemmal Voltage-Dependent Anion Channel-1

Neuronal Protection by Ha-RAS-GTPase Signaling through Selective Downregulation of Plasmalemmal Voltage-Dependent Anion Channel-1

The small GTPase RAS acts as a plasma membrane-anchored intracellular neurotrophin counteracting neuronal degeneration in the brain, but the underlying molecular mechanisms are largely unknown. In transgenic mice expressing constitutively activated V12-Ha-RAS selectively in neurons, proteome analysi...

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Bibliographic Details
Main Authors: Sebastian Neumann, Konstantin Kuteykin-Teplyakov, Rolf Heumann
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
RAS-GTPase
neuroprotection
signal transduction
transgenic mouse
VDAC-1
Online Access:https://www.mdpi.com/1422-0067/25/5/3030

Internet

https://www.mdpi.com/1422-0067/25/5/3030

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