Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Abstract Background Circular RNAs (circRNAs) can be encapsulated into exosomes to participate in intercellular communication, affecting the malignant progression of a variety of tumors. Dysfunction of CD8 + T cells is the main factor in immune escape from hepatocellular carcinoma (HCC). Nevertheless...

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Bibliographic Details
Main Authors: Zongqiang Hu, Gang Chen, Yingpeng Zhao, Hongqiang Gao, Laibang Li, Yanfeng Yin, Jie Jiang, Li Wang, Yuanyi Mang, Yang Gao, Shengning Zhang, Jianghua Ran, Li Li
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Cancer
Subjects:
circRNA
CCAR1
Hepatocellular carcinoma
Exosome
Anti-PD1
Online Access:https://doi.org/10.1186/s12943-023-01759-1

Internet

https://doi.org/10.1186/s12943-023-01759-1

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