Involvement of a Multidrug Efflux Pump and Alterations in Cell Surface Structure in the Synergistic Antifungal Activity of Nagilactone E and Anethole against Budding Yeast <i>Saccharomyces cerevisiae</i>

Involvement of a Multidrug Efflux Pump and Alterations in Cell Surface Structure in the Synergistic Antifungal Activity of Nagilactone E and Anethole against Budding Yeast <i>Saccharomyces cerevisiae</i>

Nagilactone E, an antifungal agent derived from the root bark of <i>Podocarpus nagi</i>, inhibits 1,3-β glucan synthesis; however, its inhibitory activity is weak. Anethole, the principal component of anise oil, enhances the antifungal activity of nagilactone E. We aimed to determine the...

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Bibliographic Details
Main Authors: Yuki Ueda, Yuhei O. Tahara, Makoto Miyata, Akira Ogita, Yoshihiro Yamaguchi, Toshio Tanaka, Ken-ichi Fujita
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Antibiotics
Subjects:
antifungal
nagilactone E
drug resistance
multidrug efflux pump
quick-freeze deep-etch electron microscopy
Online Access:https://www.mdpi.com/2079-6382/10/5/537

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https://www.mdpi.com/2079-6382/10/5/537

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