JNK signaling activation in the Ube3a maternal deficient mouse model: its specific inhibition prevents post-synaptic protein-enriched fraction alterations and cognitive deficits in Angelman Syndrome model

JNK signaling activation in the Ube3a maternal deficient mouse model: its specific inhibition prevents post-synaptic protein-enriched fraction alterations and cognitive deficits in Angelman Syndrome model

Deficiency of the E3 ubiquitin ligase UBE3A leads to the neurodevelopmental disorder Angelman syndrome (AS), while higher levels are linked to autism spectrum disorder. The mechanisms underlying the downstream effects of UBE3A loss or gain of function in these disorders are still not well understood...

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Bibliographic Details
Main Authors: Clara Alice Musi, Graziella Agrò, Lucia Buccarello, Serena Camuso, Tiziana Borsello
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Neurodevelopmental disease
C-Jun-N-terminal-kinase
MAP-kinase stress pathway
Synaptic dysfunction
Neuroprotection
D-JNKI1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120300875

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http://www.sciencedirect.com/science/article/pii/S0969996120300875

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