Investigating p62 Concentrations in Cerebrospinal Fluid of Patients with Dementia: A Potential Autophagy Biomarker In Vivo?

Investigating p62 Concentrations in Cerebrospinal Fluid of Patients with Dementia: A Potential Autophagy Biomarker In Vivo?

Several studies have revealed defects in autophagy in neurodegenerative disorders including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). <i>SQSTM1</i>/p62 plays a key role in the autophagic machinery and may serve as a marker for autophagic flux in vivo. We investigated th...

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Bibliographic Details
Main Authors: Elisa Rubino, Silvia Boschi, Fausto Roveta, Andrea Marcinnò, Aurora Cermelli, Cristina Borghese, Maria Claudia Vigliani, Innocenzo Rainero
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Brain Sciences
Subjects:
<i>SQSTM1</i>/p62
biomarkers
autophagy
cerebrospinal fluid
Alzheimer’s disease
frontotemporal dementia
Online Access:https://www.mdpi.com/2076-3425/12/10/1414

Internet

https://www.mdpi.com/2076-3425/12/10/1414

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