Evaluation of a Three-Fluid Nozzle Spraying Process for Facilitating Spray Drying of Hydrophilic Polymers for the Creation of Amorphous Solid Dispersions

Evaluation of a Three-Fluid Nozzle Spraying Process for Facilitating Spray Drying of Hydrophilic Polymers for the Creation of Amorphous Solid Dispersions

Amorphous solid dispersions (ASDs) enable formulations to improve the solubility of poorly soluble active pharmaceutical ingredients (APIs). The amorphous state is reached through the disruption of the crystalline lattice of an API resulting in an increased apparent solubility with faster disintegra...

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Bibliographic Details
Main Authors: Lena Karin Mueller, Laura Halstenberg, Nicole Di Gallo, Thomas Kipping
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceutics
Subjects:
polyvinyl alcohol
amorphous solid dispersion
spray drying
spray-dried dispersion
process development
sustainability
Online Access:https://www.mdpi.com/1999-4923/15/11/2542

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https://www.mdpi.com/1999-4923/15/11/2542

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