TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer’s disease

TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer’s disease

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly affects the elderly. AD’s main features have been related to cellular and molecular events, including the aberrant aggregation of the amyloid beta peptide (Aβ), Ca2+ dyshomeostasis,...

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Bibliographic Details
Main Authors: Jessica Panes-Fernandez, Pamela A. Godoy, Javiera Gavilan, Oscar Ramírez-Molina, Carlos Felipe Burgos, Ana Marileo, Oscar Flores-Núñez, Patricio A. Castro, Gustavo Moraga-Cid, Gonzalo E. Yévenes, Carola Muñoz-Montesino, Jorge Fuentealba
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Amyloid-β peptide
Amyloid-β oligomers
Mitochondrial function
Ca2+ homeostasis
transglutaminase type 2
Alzheimer disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223003840

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http://www.sciencedirect.com/science/article/pii/S0753332223003840

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