An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates

Development of tooth shape is regulated by the enamel knot signalling centre, at least in mammals. Fgf signalling regulates differential proliferation between the enamel knot and adjacent dental epithelia during tooth development, leading to formation of the dental cusp. The presence of an enamel kn...

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Bibliographic Details
Main Authors: Alexandre P Thiery, Ariane SI Standing, Rory L Cooper, Gareth J Fraser
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/73173