Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice

Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice

Abstract Proper lipid metabolism is crucial to maintain alveolar epithelial cell (AEC) function, and excessive AEC death plays a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The mRNA expression of fatty acid synthase (FASN), a key enzyme in the production of palmitate and other f...

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Bibliographic Details
Main Authors: Hyesun Shin, Shinhee Park, Jisu Hong, Ae-Rin Baek, Junehyuk Lee, Do-Jin Kim, An-Soo Jang, Su Sie Chin, Sung Hwan Jeong, Sung-Woo Park
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-36009-3

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https://doi.org/10.1038/s41598-023-36009-3

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