Therapeutic Angiogenesis by a “Dynamic Duo”: Simultaneous Expression of HGF and VEGF165 by Novel Bicistronic Plasmid Restores Blood Flow in Ischemic Skeletal Muscle

Therapeutic Angiogenesis by a “Dynamic Duo”: Simultaneous Expression of HGF and VEGF165 by Novel Bicistronic Plasmid Restores Blood Flow in Ischemic Skeletal Muscle

Therapeutic angiogenesis is a promising strategy for relief of ischemic conditions, and gene delivery was used to stimulate blood vessels’ formation and growth. We have previously shown that intramuscular injection of a mixture containing plasmids encoding vascular endothelial growth factor (VEGF)16...

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Bibliographic Details
Main Authors: Ekaterina Slobodkina, Maria Boldyreva, Maxim Karagyaur, Roman Eremichev, Natalia Alexandrushkina, Vadim Balabanyan, Zhanna Akopyan, Yelena Parfyonova, Vsevolod Tkachuk, Pavel Makarevich
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceutics
Subjects:
gene therapy
plasmids
bicistronic vector
angiogenic growth factors
limb ischemia
therapeutic angiogenesis
Online Access:https://www.mdpi.com/1999-4923/12/12/1231

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https://www.mdpi.com/1999-4923/12/12/1231

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