Population Pharmacokinetic Study of Cefathiamidine in Infants With Augmented Renal Clearance

Population Pharmacokinetic Study of Cefathiamidine in Infants With Augmented Renal Clearance

Objectives: Augmented renal clearance (ARC) of primarily renally eliminated antibacterial agents may result in subtherapeutic antibiotic concentrations and, as a consequence, worse clinical outcomes. Cefathiamidine is frequently used as empirical antimicrobial therapy in children with ARC, but pharm...

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Bibliographic Details
Main Authors: Bin Du, Yue Zhou, Bo-Hao Tang, Yue-E Wu, Xin-Mei Yang, Hai-Yan Shi, Bu-Fan Yao, Guo-Xiang Hao, Dian-Ping You, John van den Anker, Yi Zheng, Wei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
cefathiamidine
pharmacokinetics
dosing
infants
augmented renal clearance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.630047/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.630047/full

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