Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells

Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells

The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as the master regulator of antioxidant and cytoprotective gene expressions. Moreover, it plays a pivotal role in cancer progression. Nrf2 mediates the adaptive response which contributes to the resistance to ch...

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Bibliographic Details
Main Authors: Leanne Ambrosio, Monica Argenziano, Marie Angèle Cucci, Margherita Grattarola, Inge A.M. de Graaf, Chiara Dianzani, Giuseppina Barrera, Javier Sánchez Nieves, Rafael Gomez, Roberta Cavalli, Stefania Pizzimenti
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Antioxidants
Subjects:
carbosilane dendrimers
small interfering RNA (siRNA)
nuclear factor erythroid 2-related factor 2 (Nrf2)
bladder cancer
cisplatin resistance
non-cancerous HK-2 cells
Online Access:https://www.mdpi.com/2076-3921/9/10/993

Internet

https://www.mdpi.com/2076-3921/9/10/993

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