Investigation of PALB2 Mutation and Correlation With Immunotherapy Biomarker in Chinese Non-Small Cell Lung Cancer Patients

Investigation of PALB2 Mutation and Correlation With Immunotherapy Biomarker in Chinese Non-Small Cell Lung Cancer Patients

BackgroundPALB2, a gene in the homologous recombination repair (HRR) pathway of the DNA damage response (DDR), is associated with the efficacy of platinum-based chemotherapy, immunotherapy, and PARP inhibitor therapy in several tumors. However, the PALB2 characteristics, its correlation with immunot...

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Bibliographic Details
Main Authors: Jiexia Zhang, Shuangfeng Tang, Chunning Zhang, Mingyao Li, Yating Zheng, Xue Hu, Mengli Huang, Xiangyang Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
PALB2
immunotherapy
HRR
DDR
NGS
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.742833/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.742833/full

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