MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7

MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7

Abstract Background Various stimuli, including Clonorchis sinensis infection, can cause liver fibrosis. Liver fibrosis is characterized by the activation of hepatic stellate cells (HSCs) with massive production of extracellular matrix (ECM). Our previous study showed that the TGF-β1-induced Smad sig...

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Bibliographic Details
Main Authors: Qian-Yang Zhou, Hui-Min Yang, Ji-Xin Liu, Na Xu, Jing Li, Li-Ping Shen, Yu-Zhao Zhang, Stephane Koda, Bei-Bei Zhang, Qian Yu, Jia-Xu Chen, Kui-Yang Zheng, Chao Yan
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Parasites & Vectors
Subjects:
miR-497
Smad7
TGF-β/Smad signaling pathway
Hepatic fibrosis
ESPs of C. sinensis
Online Access:https://doi.org/10.1186/s13071-021-04972-3

Internet

https://doi.org/10.1186/s13071-021-04972-3

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