Mechanistic Action of Cell Cycle Arrest and Intrinsic Apoptosis via Inhibiting Akt/mTOR and Activation of p38-MAPK Signaling Pathways in Hep3B Liver Cancer Cells by Prunetrin—A Flavonoid with Therapeutic Potential

Mechanistic Action of Cell Cycle Arrest and Intrinsic Apoptosis via Inhibiting Akt/mTOR and Activation of p38-MAPK Signaling Pathways in Hep3B Liver Cancer Cells by Prunetrin—A Flavonoid with Therapeutic Potential

Hepatocellular carcinoma (HCC) has a poor prognosis and a low survival rate. Drugs without side effects are desperately needed since chemotherapy has a negative effect on the host cells. Previous research has firmly established that plant-based compounds have significant bioactivities without a nega...

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Bibliographic Details
Main Authors: Abuyaseer Abusaliya, Se Hyo Jeong, Pritam Bhagwan Bhosale, Hun Hwan Kim, Min Yeong Park, Eunhye Kim, Chung Kil Won, Kwang Il Park, Jeong Doo Heo, Hyun Wook Kim, Meejung Ahn, Je Kyung Seong, Gon Sup Kim
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Nutrients
Subjects:
flavonoids
liver cancer
Hep3B cells
cell cycle arrest
apoptosis
Online Access:https://www.mdpi.com/2072-6643/15/15/3407

Internet

https://www.mdpi.com/2072-6643/15/15/3407

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