Pharmacokinetics/pharmacodynamics of polymyxin B in patients with bloodstream infection caused by carbapenem-resistant Klebsiella pneumoniae

Pharmacokinetics/pharmacodynamics of polymyxin B in patients with bloodstream infection caused by carbapenem-resistant Klebsiella pneumoniae

Introduction: Polymyxin B is a last-line therapy for carbapenem-resistant microorganisms. However, a lack of clinical pharmacokinetic/pharmacodynamic (PK/PD) data has substantially hindered dose optimization and breakpoint setting.Methods: A prospective, multi-center clinical trial was undertaken wi...

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Bibliographic Details
Main Authors: Zhenwei Yu, Xiaofen Liu, Xiaoxing Du, Huiying Chen, Feng Zhao, Zhihui Zhou, Yu Wang, Yang Zheng, Phillip J. Bergen, Xi Li, Renhua Sun, Li Fang, Wanzhen Li, Yaxin Fan, Hailan Wu, Beining Guo, Jian Li, Yunsong Yu, Jing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
polymyxins
pharmacokinetics/pharmacodynamics
CRKP
bloodstream infection
neurotoxicity
nephrotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.975066/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.975066/full

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