Engineered Fully Human Single-Chain Monoclonal Antibodies to PIM2 Kinase

Engineered Fully Human Single-Chain Monoclonal Antibodies to PIM2 Kinase

Proviral integration site of Moloney virus-2 (PIM2) is overexpressed in multiple human cancer cells and high level is related to poor prognosis; thus, PIM2 kinase is a rational target of anti-cancer therapeutics. Several chemical inhibitors targeting PIMs/PIM2 or their downstream signaling molecules...

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Bibliographic Details
Main Authors: Kanasap Kaewchim, Kittirat Glab-ampai, Kodchakorn Mahasongkram, Monrat Chulanetra, Watee Seesuay, Wanpen Chaicumpa, Nitat Sookrung
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
human scFv
phage display
PIM2 kinase
ATP-binding pocket
homology modeling
intermolecular docking
Online Access:https://www.mdpi.com/1420-3049/26/21/6436

Internet

https://www.mdpi.com/1420-3049/26/21/6436

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