Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis.

Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis.

Endogenous carbon monoxide (CO) exerts anti-inflammatory effects. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts. Here we found that exogenous CO enhanced the decay of TNF-α mRNA and suppressed TNF-α expression in LPS-activated macrophages from wild-type (WT) mice. Howeve...

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Bibliographic Details
Main Authors: Yeonsoo Joe, Md Jamal Uddin, Min Zheng, Hyo Jeong Kim, Yingqing Chen, Nal Ae Yoon, Gyeong Jae Cho, Jeong Woo Park, Hun Taeg Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088776&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088776&type=printable

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